Legend Axial T2-WI as well as axial FLAIR at the level of the basal ganglia demonstrate near symmetric hyperintensity located in the occipital white matter. Note the involvement of the subcortical u-fibers. To a lesser degree, the abnormal signal is also present in the overlying posterior occipital cortex.

Legend More cephalad FLAIR images demonstrate abnormal hyperintensity located also in the subcortical and deeper white matter of the frontal and parietal lobes.

Legend Coronal T1-WI suggests subtle T1 shortening in the involved areas. Post gadolinium T1WI FS images are notable for the lack of contrast enhancement. Key words: mri toxic demyelinating

Brain Diagnosis: Cyclosporin toxicity