Lissencephaly (Agyria-Pachygyria)

Most severe form of neuronal migrational anomalies. Patients often have small brains, mental retardation, spasticity, seizures.

Agyria (complete lissencephaly) presents with smooth brain and is identified by figure eight configuration with clefts extending to the sylvian fissures.

Pachygyria (incomplete lissencephaly) has broad, shallow gyre. More mild form than agyria.

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