Hamartoma of the Tuber Cinereum

            These benign tumors consist of hyperplastic hypothalamic glial and neural tissue. Patients present with precocious puberty due to disruption of the normal hypothalamic inhibition of gonadotropin production during the prepuberty years. These lesions grow very slowly and often appear unchanged on serial imaging studies.

            Hamartomas are sessile or pedunculated masses positioned between the infundibulum and mamillary bodies. They are usually isointense to brain on T1-weighted images and mildly hyperintense on T2-weighted images. The lack of contrast enhancement distinguishes these tumors from hypothalamic glioma and germinoma. Endnote  

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