Rathke's Cleft Cyst

            These benign cysts arise from remnants of Rathke's cleft in the region of the pars intermedia. They are lined by a single layer of ciliated columnar or cuboidal epithelium, often containing goblet cells. Initially intrasellar, they enlarge and extend into the suprasellar region as they accumulate fluid, mucous, and cellular debris.

            Rathke's cleft cysts are smoothly marginated and well-defined lesions. The MR signal characteristics are variable, depending on the cyst contents. The cyst capsule may enhance, but the lack of nodular enhancement helps distinguish these lesions from craniopharyngiomas. Endnote  

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