This malignancy can arise from nodal tissue of the oropharynx, especially in the region of Waldeyer's ring. These lesions are often bulky and also accompanied by large bulky lymph nodes. The most common form of lymphoma in the head and neck is non-Hodgkin's lymphoma. In fact, the head and neck region is the second most common site of non-Hodgkin's lymphoma (the first is the gastrointestinal tract). If mediastinal nodes are also present, then one may be dealing with a Hodgkin's lymphoma rather than a non-Hodgkin's lymphoma. Leukemia can present similarly with bulky lymph nodes and enlargement of Waldeyer's ring.

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